Sytl2-KO Mouse
一般名
Sytl2-KO
製品ID
S-KO-17803
背景情報
C57BL/6JCya
系統ID
KOCMP-83671-Sytl2-B6J-VB
状況
このマウス系統を論文で使用する場合は、「Sytl2-KO Mouse（カタログ番号S-KO-17803）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Sytl2-KO
系統ID
KOCMP-83671-Sytl2-B6J-VB
遺伝子名
製品ID
S-KO-17803
遺伝子別名
Slp2, mKIAA1597
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conventional knockout
染色体
Chr 7
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000190731
NCBIトランスクリプトID
NM_001289583
ターゲット領域
Exon 12~13
有効領域の大きさ
~2.7 kb
遺伝子研究の概要
Sytl2, or synaptotagmin-like 2, has been implicated in multiple biological processes and disease-related pathways. Although its exact essential function is still being elucidated, it has connections to cell migration, invasion, and immune-related processes. In cell migration, it may be involved in cytoskeletal-related mechanisms, and in the immune context, it could potentially play a role in immune cell regulation and function [1,2,7].
In prostate cancer, SYTL2 promotes metastasis by enhancing FSCN1-mediated pseudopodia formation and invasion. It binds to and inhibits the proteasome degradation pathway of FSCN1, increasing its stability and leading to enhanced cell migration, invasion, and lymph node metastasis both in vitro and in vivo [1].
In thoracic aortic aneurysm, SYTL2, along with COL1A1, may be diagnostic marker genes. Their upregulation might be involved in inflammatory infiltration of the vessel wall and poor extracellular matrix remodeling, promoting the disease progression [2].
In spinal osteosarcoma, SYTL2 is part of the miR-654-3p/SYTL2 axis targeted by lncRNA BSN-AS2, which promotes cancer progression [3].
In ovarian cancer, overexpression of SYTL2 promotes metastatic potential, including increased migration and invasiveness [4].
In alveolar soft-part sarcoma, Sytl2 is involved in the intracellular trafficking of bioactive signals during angiogenesis [5,6]. Additionally, SYTL2 has been identified as a potential diagnostic biomarker for sleep-deprivation related myocardial infarction, and is strongly associated with resting NK cells and NK cell signaling pathways [7].
In conclusion, Sytl2 plays crucial roles in cancer metastasis, disease diagnosis, and potentially in immune-related diseases. Studies on Sytl2, especially through in vivo models in cancer research, have provided valuable insights into its functions in promoting cancer cell migration and invasion, as well as its potential as a diagnostic biomarker in non-cancerous diseases. This knowledge can contribute to the development of new therapeutic strategies and diagnostic methods for related diseases.
References：
1. Li, Zean, Tao, Yiran, Gao, Ze, Chen, Xu, Huang, Hai. 2023. SYTL2 promotes metastasis of prostate cancer cells by enhancing FSCN1-mediated pseudopodia formation and invasion. In Journal of translational medicine, 21, 303. doi:10.1186/s12967-023-04146-y. https://pubmed.ncbi.nlm.nih.gov/37147713/
2. Xie, Xinsheng, Yuan, Ye, Huang, Yulong, Fu, Weiguo, Wang, Lixin. 2023. Effects of COL1A1 and SYTL2 on inflammatory cell infiltration and poor extracellular matrix remodeling of the vascular wall in thoracic aortic aneurysm. In Chinese medical journal, 137, 1105-1114. doi:10.1097/CM9.0000000000002808. https://pubmed.ncbi.nlm.nih.gov/37640670/
3. Zhou, Xianwei, Li, Jitian, Teng, Junyan, Liu, Linyun, Zhang, Wenming. 2020. Long noncoding RNA BSN-AS2 induced by E2F1 promotes spinal osteosarcoma progression by targeting miR-654-3p/SYTL2 axis. In Cancer cell international, 20, 133. doi:10.1186/s12935-020-01205-y. https://pubmed.ncbi.nlm.nih.gov/32351327/
4. Sung, Hye Youn, Han, Jihye, Ju, Woong, Ahn, Jung-Hyuck. 2016. Synaptotagmin-like protein 2 gene promotes the metastatic potential in ovarian cancer. In Oncology reports, 36, 535-41. doi:10.3892/or.2016.4835. https://pubmed.ncbi.nlm.nih.gov/27220283/
5. Chuaychob, Surachada, Lyu, Ruyin, Tanaka, Miwa, Nakamura, Takuro, Yokokawa, Ryuji. 2024. Mimicking angiogenic microenvironment of alveolar soft-part sarcoma in a microfluidic coculture vasculature chip. In Proceedings of the National Academy of Sciences of the United States of America, 121, e2312472121. doi:10.1073/pnas.2312472121. https://pubmed.ncbi.nlm.nih.gov/38502703/
6. Tanaka, Miwa, Chuaychob, Surachada, Homme, Mizuki, Yokokawa, Ryuji, Nakamura, Takuro. 2023. ASPSCR1::TFE3 orchestrates the angiogenic program of alveolar soft part sarcoma. In Nature communications, 14, 1957. doi:10.1038/s41467-023-37049-z. https://pubmed.ncbi.nlm.nih.gov/37029109/
7. Chen, Xiang, Li, Qian, Zhang, Zhong, Yang, Minjing, Wang, E. 2022. Identification of Potential Diagnostic Biomarkers From Circulating Cells During the Course of Sleep Deprivation-Related Myocardial Infarction Based on Bioinformatics Analyses. In Frontiers in cardiovascular medicine, 9, 843426. doi:10.3389/fcvm.2022.843426. https://pubmed.ncbi.nlm.nih.gov/35369343/
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凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
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