Syk-KO Mouse
一般名
Syk-KO
製品ID
S-KO-17981
背景情報
C57BL/6JCya
系統ID
KOCMP-20963-Syk-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Syk-KO Mouse（カタログ番号S-KO-17981）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Syk-KO
系統ID
KOCMP-20963-Syk-B6J-VA
遺伝子名
製品ID
S-KO-17981
遺伝子別名
Sykb
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conventional knockout
染色体
Chr 13
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000120135
NCBIトランスクリプトID
NM_001198977
ターゲット領域
Exon 3
有効領域の大きさ
~1.8 kb
遺伝子研究の概要
Syk, short for spleen tyrosine kinase, is a non-receptor tyrosine kinase. It is highly expressed in hematopoietic cells and plays crucial roles in diverse biological functions. It is a key player in adaptive immune receptor signalling, and also mediates processes like cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation, and vascular development. It is activated by C-type lectins and integrins, and activates pathways such as the CARD9-BCL-10-MALT1 pathway and the NLRP3 inflammasome [1].
Syk has been implicated in numerous diseases. In autoimmune diseases like immune thrombocytopenia (ITP), rheumatoid arthritis, and systemic lupus erythematosus, Syk-signaling pathway is a potential target for treatment. Fostamatinib, a Syk inhibitor, has shown clinical response in ITP patients, including those refractory to other treatments [2,7]. In hematological malignancies, Syk is recognized as a critical element in the B-cell receptor signaling pathway, and several oral Syk inhibitors are being assessed in clinical trials [3]. In solid tumors, it shows a paradoxical role, acting as a tumor suppressor in some cancers while driving tumor growth in others [4]. In cardio-cerebrovascular diseases such as atherosclerosis, heart failure, and diabetic cardiomyopathy, Syk is involved in their progression [5]. Also, in Helicobacter pylori-induced gastric mucosal inflammatory responses, Syk activation leads to up-regulation of proinflammatory genes [6].
In conclusion, Syk is essential for multiple biological functions from immune responses to cell-cell interactions. The study of Syk using various models, potentially including KO/CKO mouse models (although not explicitly detailed in the given references about these models), has significantly contributed to understanding its role in diseases like autoimmune disorders, hematological malignancies, solid tumors, cardio-cerebrovascular diseases, and gastric inflammatory responses. This knowledge provides a basis for developing therapeutic strategies targeting Syk.
References：
1. Mócsai, Attila, Ruland, Jürgen, Tybulewicz, Victor L J. . The SYK tyrosine kinase: a crucial player in diverse biological functions. In Nature reviews. Immunology, 10, 387-402. doi:10.1038/nri2765. https://pubmed.ncbi.nlm.nih.gov/20467426/
2. Cooper, Nichola, Ghanima, Waleed, Hill, Quentin A, Markovtsov, Vadim, Kessler, Craig. 2022. Recent advances in understanding spleen tyrosine kinase (SYK) in human biology and disease, with a focus on fostamatinib. In Platelets, 34, 2131751. doi:10.1080/09537104.2022.2131751. https://pubmed.ncbi.nlm.nih.gov/36331249/
3. Liu, Delong, Mamorska-Dyga, Aleksandra. 2017. Syk inhibitors in clinical development for hematological malignancies. In Journal of hematology & oncology, 10, 145. doi:10.1186/s13045-017-0512-1. https://pubmed.ncbi.nlm.nih.gov/28754125/
4. Joshi, Shweta. 2024. New insights into SYK targeting in solid tumors. In Trends in pharmacological sciences, 45, 904-918. doi:10.1016/j.tips.2024.08.006. https://pubmed.ncbi.nlm.nih.gov/39322438/
5. Li, Mohan, Wang, Pengbo, Zou, Yuanming, Zhang, Naijin, Sun, Yingxian. 2023. Spleen tyrosine kinase (SYK) signals are implicated in cardio-cerebrovascular diseases. In Heliyon, 9, e15625. doi:10.1016/j.heliyon.2023.e15625. https://pubmed.ncbi.nlm.nih.gov/37180910/
6. Slomiany, Bronislaw L, Slomiany, Amalia. 2019. Syk: a new target for attenuation of Helicobacter pylori-induced gastric mucosal inflammatory responses. In Inflammopharmacology, 27, 203-211. doi:10.1007/s10787-019-00577-6. https://pubmed.ncbi.nlm.nih.gov/30820719/
7. Deng, Guo-Min, Kyttaris, Vasileios C, Tsokos, George C. 2016. Targeting Syk in Autoimmune Rheumatic Diseases. In Frontiers in immunology, 7, 78. doi:10.3389/fimmu.2016.00078. https://pubmed.ncbi.nlm.nih.gov/27014261/
品質管理基準
精子検査
凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
環境基準:
SPF対応地域:
グローバル由来:
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