Lrrc37a-KO Mouse
一般名
Lrrc37a-KO
製品ID
S-KO-18188
背景情報
C57BL/6JCya
系統ID
KOCMP-237954-Lrrc37a-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Lrrc37a-KO Mouse（カタログ番号S-KO-18188）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Lrrc37a-KO
系統ID
KOCMP-237954-Lrrc37a-B6J-VA
遺伝子名
製品ID
S-KO-18188
遺伝子別名
Gm251
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conventional knockout
染色体
Chr 11
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000153273
NCBIトランスクリプトID
XM_011249376
ターゲット領域
Exon 1
有効領域の大きさ
~6.7 kb
遺伝子研究の概要
Lrrc37a is a gene located within the 17q21.31 locus. It is a membrane-associated protein that has been implicated in multiple biological functions. In terms of associated pathways, it may be involved in cellular migration, chemotaxis, and astroglial inflammation [2]. It also seems to play a role in the context of neurodegenerative diseases, making it of significant biological importance. Genetic models such as gene knockout (KO) or conditional knockout (CKO) mouse models could potentially be valuable for further studying its functions.
In post-traumatic stress disorder (PTSD) and major depressive disorder (MDD), Lrrc37a was among the genes identified through single-nucleus RNA-seq analysis of the dorsolateral prefrontal cortex. In MDD samples, it was one of the differentially expressed genes, while in PTSD, genes from the 17q21.31 locus including Lrrc37a2 were identified, highlighting cell-type-specific mechanisms of brain stress response [1]. In Parkinson's disease (PD), the 17q21.31 locus is genetically associated with the disease. Protective sub-haplotypes were associated with increased Lrrc37a/2 copy number and expression in human brain tissue. Lrrc37a/2 was found to interact directly with soluble α-synuclein and co-localize with Lewy bodies in PD brain tissue, indicating its contribution to the association between the 17q21.31 locus and PD [2]. In progressive supranuclear palsy (PSP), γ duplication within the 17q21.31 region up-regulates the expression of Lrrc37a/Lrrc37a2 in neuronal cells, and the copy number of γ is associated with the risk of PSP [3].
In conclusion, Lrrc37a is a gene with functions related to cellular processes like migration and inflammation, and is associated with neurodegenerative diseases such as PD and PSP, as well as mental disorders like PTSD and MDD. Studies on Lrrc37a using KO or CKO mouse models could potentially further clarify its role in these disease conditions, providing insights into the underlying biological mechanisms and potentially leading to new therapeutic strategies [1,2,3].
References：
1. Chatzinakos, Chris, Pernia, Cameron D, Morrison, Filomene G, Ressler, Kerry J, Daskalakis, Nikolaos P. 2023. Single-Nucleus Transcriptome Profiling of Dorsolateral Prefrontal Cortex: Mechanistic Roles for Neuronal Gene Expression, Including the 17q21.31 Locus, in PTSD Stress Response. In The American journal of psychiatry, 180, 739-754. doi:10.1176/appi.ajp.20220478. https://pubmed.ncbi.nlm.nih.gov/37491937/
2. Bowles, Kathryn R, Pugh, Derian A, Liu, Yiyuan, Crary, John F, Goate, A M. 2022. 17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson's disease are associated with LRRC37A/2 expression in astrocytes. In Molecular neurodegeneration, 17, 48. doi:10.1186/s13024-022-00551-x. https://pubmed.ncbi.nlm.nih.gov/35841044/
3. Wang, Hui, Chang, Timothy S, Dombroski, Beth A, Schellenberg, Gerard D, Lee, Wan-Ping. 2025. Copy Number Variation and Haplotype Analysis of 17q21.31 Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells. In Movement disorders : official journal of the Movement Disorder Society, , . doi:10.1002/mds.30150. https://pubmed.ncbi.nlm.nih.gov/40055946/
品質管理基準
精子検査
凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
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グローバル由来:
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