Mgst2-KO Mouse

Mgst2, microsomal glutathione S-transferase 2, is a member of the MAPEG superfamily. It is involved in leukotriene C4 production, which is crucial for intracrine signaling of endoplasmic reticulum stress, oxidative DNA damage, and cell death. It also participates in the regulation of the oxidative stress pathway [1,2].

In a study, Mgst2-gene-deficient mice were generated by CRISPR/Cas9-mediated gene editing. Morphometric analysis showed that the height, width, and volume of the eyeballs in Mgst2 KO homozygous mice were significantly greater than those of wild-type mice, indicating a potential contribution to the development of a subgroup of strabismus. Additionally, Mgst2 was identified as a candidate gene for comitant strabismus susceptibility in Japanese patients [3,4]. In another study, coniferyl ferulate was found to alleviate xylene-caused hematopoietic stem and progenitor cell toxicity by targeting Mgst2, especially in neutrophil progenitor subpopulations [5].

In conclusion, Mgst2 plays essential roles in leukotriene C4 synthesis and oxidative stress regulation. The Mgst2-KO mouse model has provided insights into its role in eye development and strabismus. Research on Mgst2 also reveals its potential as a therapeutic target for xylene-induced hematotoxicity.