Serpind1-KO Mouse
一般名
Serpind1-KO
製品ID
S-KO-18880
背景情報
C57BL/6JCya
系統ID
KOCMP-15160-Serpind1-B6J-VB
状況
このマウス系統を論文で使用する場合は、「Serpind1-KO Mouse（カタログ番号S-KO-18880）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Serpind1-KO
系統ID
KOCMP-15160-Serpind1-B6J-VB
遺伝子名
製品ID
S-KO-18880
遺伝子別名
HCII, Hcf2, HC-II
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conventional knockout
染色体
Chr 16
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000023450
NCBIトランスクリプトID
NM_008223
ターゲット領域
Exon 3
有効領域の大きさ
~0.3 kb
遺伝子研究の概要
Serpind1, also known as heparin cofactor II, belongs to the serine protease inhibitor family. Some serpins, including Serpind1, utilize glycosaminoglycans (GAGs) to enhance the inhibition of target proteases [2].
In epithelial ovarian cancer, Serpind1 expression is significantly elevated, and high expression is associated with poor prognosis. Serpind1 promotes the proliferation, migration, invasion, G1-to-S phase transition, and epithelial-mesenchymal transition of ovarian cancer cells, while inhibiting apoptosis by promoting phosphorylation in the PI3K/AKT pathway. Inhibition of Serpind1 expression in ovarian cancer cells has opposite effects, and adding the PI3K/AKT pathway inhibitor to Serpind1-overexpressing cells can reverse its promoting effect on the malignant biological behavior of ovarian cancer cells [1].
In glaucoma, Serpind1 shows significant upregulation and plays a vital role in glaucoma occurrences, being associated with eye transparency decrease and glucose metabolism [3].
In patients with systemic sclerosis-associated pulmonary hypertension, the expression of Serpind1 is increased in the survivor group compared to the non-survivor group [4].
In intrahepatic cholestasis of pregnancy, the expression level of Serpind1 is remarkably lower in ICP patients than in healthy pregnant females, and it has a negative correlation with total bile acid (TBA) [5]. Polycyclic aromatic hydrocarbons (PAHs) accelerate the development of arteriosclerosis by promoting the expression of miR-155 to downregulate Serpind1 [6].
In conclusion, Serpind1 is a serine protease inhibitor that can interact with GAGs. Through studies in various disease models, it has been shown to play important roles in cancer (such as epithelial ovarian cancer), glaucoma, systemic sclerosis-associated pulmonary hypertension, intrahepatic cholestasis of pregnancy, and atherosclerosis. These findings from different disease-related research help to understand its biological functions and the potential for it to be a biomarker or therapeutic target in these diseases.
References：
1. Guo, Qian, Zhu, Liancheng, Wang, Caixia, Li, Xiao, Lin, Bei. 2019. SERPIND1 Affects the Malignant Biological Behavior of Epithelial Ovarian Cancer via the PI3K/AKT Pathway: A Mechanistic Study. In Frontiers in oncology, 9, 954. doi:10.3389/fonc.2019.00954. https://pubmed.ncbi.nlm.nih.gov/31637210/
2. Rein, Chantelle M, Desai, Umesh R, Church, Frank C. . Serpin-glycosaminoglycan interactions. In Methods in enzymology, 501, 105-37. doi:10.1016/B978-0-12-385950-1.00007-9. https://pubmed.ncbi.nlm.nih.gov/22078533/
3. Liu, Xiaoyan, Liu, Xiang, Wang, Ying, Xu, Jiyu, Sun, Wei. 2021. Proteome Characterization of Glaucoma Aqueous Humor. In Molecular & cellular proteomics : MCP, 20, 100117. doi:10.1016/j.mcpro.2021.100117. https://pubmed.ncbi.nlm.nih.gov/34214668/
4. Mismetti, Valentine, Delavenne, Xavier, Montani, David, Bertoletti, Laurent, Cottin, Vincent. 2023. Proteomic biomarkers for survival in systemic sclerosis-associated pulmonary hypertension. In Respiratory research, 24, 273. doi:10.1186/s12931-023-02578-0. https://pubmed.ncbi.nlm.nih.gov/37936223/
5. Chen, Lingyan, Li, Jingyang, You, Yilan, Xiao, Jianping, Zhang, Yan. 2023. Secreted proteins in plasma and placenta as novel non-invasive biomarkers for intrahepatic cholestasis of pregnancy: A case-control study. In Heliyon, 9, e21616. doi:10.1016/j.heliyon.2023.e21616. https://pubmed.ncbi.nlm.nih.gov/38027820/
6. He, Xiao-Nan, Xin, Jin-Yuan, Zhan, Jin-Liang, Zhang, Xiao-Ling, Bai, Ying-Chen. 2021. Polycyclic aromatic hydrocarbons induce endothelial injury through miR-155 to promote atherosclerosis. In Environmental and molecular mutagenesis, 62, 409-421. doi:10.1002/em.22454. https://pubmed.ncbi.nlm.nih.gov/34331478/
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凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
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