Ankrd13d-KO Mouse
一般名
Ankrd13d-KO
製品ID
S-KO-19810
背景情報
C57BL/6JCya
系統ID
KOCMP-68423-Ankrd13d-B6J-VB
状況
このマウス系統を論文で使用する場合は、「Ankrd13d-KO Mouse（カタログ番号S-KO-19810）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Ankrd13d-KO
系統ID
KOCMP-68423-Ankrd13d-B6J-VB
遺伝子名
製品ID
S-KO-19810
遺伝子別名
0710001P18Rik
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conventional knockout
染色体
Chr 19
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000056888
NCBIトランスクリプトID
NM_026720
ターゲット領域
Exon 2~6
有効領域の大きさ
~2.6 kb
遺伝子研究の概要
Ankrd13d, short for Ankyrin repeat domain-containing protein 13D, is involved in multiple biological processes. It contains ubiquitin-interacting motifs (UIM) and may act as a molecular scaffold in the endocytic pathway [2,3]. It has potential importance in diseases, as genes in the endocytic pathway, including Ankrd13d, may contribute to Alzheimer's disease [3].
In renal cell carcinoma, Ankrd13d was identified as a key immune regulator. It is mainly expressed in immune cells, positively correlated with Treg cell infiltration, and also with immune-related genes like PDCD1, CTLA4, etc. Targeting Ankrd13d with immune checkpoints blockade may be a promoting strategy for renal cell carcinoma immunotherapy [1].
In addition, in the context of heart failure, Ankrd13d was identified as a potential genetic contributor through an integrative transomics approach, although independent replication is needed [4]. Genome-wide association studies also found that Ankrd13d is associated with arachidonic acid in Hispanic Americans, indicating its role in fatty acid-related genetics [5,6]. In clear cell renal cell carcinoma, Ankrd13d has a strong positive correlation with TRIM46, suggesting its potential involvement in tumor-associated pathways [7].
In summary, Ankrd13d is implicated in immune regulation, endocytic processes, heart failure, fatty acid genetics, and renal cell carcinoma-related pathways. The findings from these studies contribute to understanding its role in various biological processes and disease conditions, potentially guiding future research and therapeutic strategies.
References：
1. Zhou, Wenqian, Huang, Yonghe, Liu, Jing, Liu, Yuqing, Yu, Chen. 2024. Identification of ANKRD13D as a potential target in renal cell carcinomas. In The International journal of biological markers, 39, 149-157. doi:10.1177/03936155241236498. https://pubmed.ncbi.nlm.nih.gov/38449090/
2. Mattioni, Anna, Boldt, Karsten, Auciello, Giulio, Cesareni, Gianni, Santonico, Elena. 2020. Ring Finger Protein 11 acts on ligand-activated EGFR via the direct interaction with the UIM region of ANKRD13 protein family. In The FEBS journal, 287, 3526-3550. doi:10.1111/febs.15226. https://pubmed.ncbi.nlm.nih.gov/31985874/
3. Zhan, Lingyu, Li, Jiajin, Jew, Brandon, Sul, Jae Hoon. 2021. Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences. In PLoS genetics, 17, e1009772. doi:10.1371/journal.pgen.1009772. https://pubmed.ncbi.nlm.nih.gov/34516545/
4. Andersson, Charlotte, Lin, Honghuang, Liu, Chunyu, Larson, Martin G, Vasan, Ramachandran S. 2019. Integrated Multiomics Approach to Identify Genetic Underpinnings of Heart Failure and Its Echocardiographic Precursors: Framingham Heart Study. In Circulation. Genomic and precision medicine, 12, e002489. doi:10.1161/CIRCGEN.118.002489. https://pubmed.ncbi.nlm.nih.gov/31703168/
5. Yang, Chaojie, Veenstra, Jenna, Bartz, Traci M, Lemaitre, Rozenn N, Manichaikul, Ani. 2023. Genome-wide association studies and fine-mapping identify genomic loci for n-3 and n-6 polyunsaturated fatty acids in Hispanic American and African American cohorts. In Communications biology, 6, 852. doi:10.1038/s42003-023-05219-w. https://pubmed.ncbi.nlm.nih.gov/37587153/
6. Yang, Chaojie, Veenstra, Jenna, Bartz, Traci, Lemaitre, Rozenn, Manichaikul, Ani. 2023. Genome-Wide Association Studies and fine-mapping of genomic loci for n-3 and n-6 Polyunsaturated Fatty Acids in Hispanic American and African American Cohorts. In Research square, , . doi:10.21203/rs.3.rs-2073736/v1. https://pubmed.ncbi.nlm.nih.gov/36865120/
7. Ren, Xiang-Bin, Zhao, Jing, Liang, Xue-Feng, Jiang, Shao-Bo, Xiang, Yu-Zhu. 2021. Identification TRIM46 as a Potential Biomarker and Therapeutic Target for Clear Cell Renal Cell Carcinoma Through Comprehensive Bioinformatics Analyses. In Frontiers in medicine, 8, 785331. doi:10.3389/fmed.2021.785331. https://pubmed.ncbi.nlm.nih.gov/34881275/
品質管理基準
精子検査
凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
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SPF対応地域:
グローバル由来:
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