Fkbp11-KO Mouse
一般名
Fkbp11-KO
製品ID
S-KO-20306
背景情報
C57BL/6JCya
系統ID
KOCMP-66120-Fkbp11-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Fkbp11-KO Mouse（カタログ番号S-KO-20306）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Fkbp11-KO
系統ID
KOCMP-66120-Fkbp11-B6J-VA
遺伝子名
製品ID
S-KO-20306
遺伝子別名
FKBP-11, 1110002O23Rik
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conventional knockout
染色体
Chr 15
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000003445
NCBIトランスクリプトID
NM_024169
ターゲット領域
Exon 1~5
有効領域の大きさ
~2.4 kb
遺伝子研究の概要
Fkbp11, also known as FK506-binding protein 11, is a member of the peptidyl-prolyl cis-trans isomerase family. It is involved in the unfolded protein response (UPR) pathway and acts as a translocon accessory factor during the synthesis of soluble secretory and transmembrane proteins at the endoplasmic reticulum (ER) [6]. It also has connections to various biological processes such as cell growth, proliferation, and apoptosis, making it biologically important in understanding disease mechanisms.
In obese mice, restoring hepatic Fkbp11 expression initiates an atypical UPR signaling pathway. It rewires PERK signaling toward NRF2, away from the eIF2α-ATF4 axis of the UPR, establishing glucose homeostasis without changing hepatic ER stress, food consumption, or body weight. This indicates that Fkbp11 could be a potential target to treat type 2 diabetes and obesity related to ER stress [1].
In hepatocellular carcinoma (HCC), Fkbp11 is upregulated, and knockdown of Fkbp11 in HCC cells attenuates proliferation and migration, suggesting its role in HCC pathogenesis. Its levels are significantly reduced post-surgery, making it a potential diagnostic and prognostic marker for HCC [2].
In osteosarcoma, Fkbp11 is highly expressed, and silencing its expression suppresses cell invasion, migration, slows proliferation, and promotes apoptosis through the MAPK pathway [3].
In oral squamous cell carcinoma (OSCC), FKBP11 promotes cell proliferation by regulating the G2/M phase and apoptosis via p53-related pathways [4].
In Crohn's disease, increased FKBP11 expression in intestinal inflammatory tissues protects intestinal epithelial cells against inflammation-induced apoptosis via the JNK-caspase pathway [5].
In conclusion, Fkbp11 plays crucial roles in multiple biological processes and disease conditions. Model-based research, especially using gene knockout or conditional knockout mouse models, has revealed its significance in diseases like type 2 diabetes, obesity, and various cancers. Understanding Fkbp11's functions provides potential targets for developing novel therapeutic strategies for these diseases.
References：
1. Herrema, Hilde, Guan, Dongxian, Choi, Jae Won, Chun, Hyonho, Ozcan, Umut. . FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity. In Cell metabolism, 34, 1004-1022.e8. doi:10.1016/j.cmet.2022.06.007. https://pubmed.ncbi.nlm.nih.gov/35793654/
2. Thokerunga, Erick, Huang, Fangfang, Bongolo, Christian Cedric, Akankwatsa, Gilbert, Tu, Jian-Cheng. . FKBP11 upregulation promotes proliferation and migration in hepatocellular carcinoma. In Cancer biomarkers : section A of Disease markers, 37, 109-120. doi:10.3233/CBM-220440. https://pubmed.ncbi.nlm.nih.gov/37248890/
3. Zeng, Duo, Li, Jiayu, Yuan, Xuhui, Lv, Xiao-Bin, Liao, Qi. 2023. FKBP11 improves the malignant property of osteosarcoma cells and acts as a prognostic factor of osteosarcoma. In Aging, 15, 2450-2459. doi:10.18632/aging.204523. https://pubmed.ncbi.nlm.nih.gov/37014329/
4. Qiu, Lin, Liu, Han, Wang, Shuang, Wang, Guan-Hua, Zhang, Jun. 2021. FKBP11 promotes cell proliferation and tumorigenesis via p53-related pathways in oral squamous cell carcinoma. In Biochemical and biophysical research communications, 559, 183-190. doi:10.1016/j.bbrc.2021.04.096. https://pubmed.ncbi.nlm.nih.gov/33945996/
5. Wang, Xiaotong, Cui, Xiaopeng, Zhu, Chuanwu, Zhang, Dongmei, Zhou, Guoxiong. 2018. FKBP11 protects intestinal epithelial cells against inflammation‑induced apoptosis via the JNK‑caspase pathway in Crohn's disease. In Molecular medicine reports, 18, 4428-4438. doi:10.3892/mmr.2018.9485. https://pubmed.ncbi.nlm.nih.gov/30221722/
6. DiGuilio, Amanda, Cheng, Ben, Zhong, Frank, Coon, Joshua J, Keenan, Robert J. 2024. The prolyl isomerase FKBP11 is a secretory translocon accessory factor. In Molecular biology of the cell, 35, ar135. doi:10.1091/mbc.E24-07-0305. https://pubmed.ncbi.nlm.nih.gov/39259761/
品質管理基準
精子検査
凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
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SPF対応地域:
グローバル由来:
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