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8 件の結果が “Il4ra” で取得されました
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ベストセラー
Il4ra-flox
製品ID :
S-CKO-03105
系統:
C57BL/6JCya
状況:
説明:
Il4ra is located on chromosome 7 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Il4ra conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Il4ra is located on chromosome 7 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Il4ra conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
huIL4RA
製品ID :
C001629
系統:
C57BL/6NCya
状況:
説明:
Interleukin-4 (IL-4) and its receptor, IL-4R, are pivotal regulators of immune responses and inflammation. The IL4 gene encodes the IL-4 cytokine, a multifunctional protein predominantly secreted by Th2 cells, mast cells, and eosinophils, while the IL4R gene encodes the IL-4 receptor, which is expressed on a variety of immune cells, including B cells, T cells, macrophages, and endothelial cells. IL-4 binds to IL-4R, which exists in two distinct forms: Type I (comprising IL-4Rα and the common γ-chain) and Type II (comprising IL-4Rα and IL-13Rα1) [1]. This interaction activates the JAK-STAT signaling pathway, driving Th2 cell differentiation, B cell class switching to IgE, and anti-inflammatory responses. The IL-4/IL-4R signaling axis is critically implicated in allergic diseases such as asthma, atopic dermatitis, and allergic rhinitis, as well as in parasitic infections and certain cancers [2-5]. Dysregulation of this pathway underlies various pathological conditions, positioning IL-4R as a promising therapeutic target. For instance, dupilumab, a monoclonal antibody targeting IL-4Rα, has been approved for the treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyps, underscoring the therapeutic potential of modulating this pathway [6-7].
huIL4RA mice are humanized models generated using gene editing technology by replacing the extracellular domain of the mouse Il4ra with the corresponding human IL4R extracellular domain, while retaining the murine signal peptide. Homozygous huIL4RA mice are viable and fertile. This model is an invaluable tool for studying allergic diseases (e.g., asthma and atopic dermatitis), Th2 immune responses, parasitic infections, tumor immunology, and chronic inflammation. Furthermore, it is a robust preclinical platform for evaluating the efficacy and mechanisms of therapeutic agents targeting the IL-4Rα.
Interleukin-4 (IL-4) and its receptor, IL-4R, are pivotal regulators of immune responses and inflammation. The IL4 gene encodes the IL-4 cytokine, a multifunctional protein predominantly secreted by Th2 cells, mast cells, and eosinophils, while the IL4R gene encodes the IL-4 receptor, which is expressed on a variety of immune cells, including B cells, T cells, macrophages, and endothelial cells. IL-4 binds to IL-4R, which exists in two distinct forms: Type I (comprising IL-4Rα and the common γ-chain) and Type II (comprising IL-4Rα and IL-13Rα1) [1]. This interaction activates the JAK-STAT signaling pathway, driving Th2 cell differentiation, B cell class switching to IgE, and anti-inflammatory responses. The IL-4/IL-4R signaling axis is critically implicated in allergic diseases such as asthma, atopic dermatitis, and allergic rhinitis, as well as in parasitic infections and certain cancers [2-5]. Dysregulation of this pathway underlies various pathological conditions, positioning IL-4R as a promising therapeutic target. For instance, dupilumab, a monoclonal antibody targeting IL-4Rα, has been approved for the treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyps, underscoring the therapeutic potential of modulating this pathway [6-7].
huIL4RA mice are humanized models generated using gene editing technology by replacing the extracellular domain of the mouse Il4ra with the corresponding human IL4R extracellular domain, while retaining the murine signal peptide. Homozygous huIL4RA mice are viable and fertile. This model is an invaluable tool for studying allergic diseases (e.g., asthma and atopic dermatitis), Th2 immune responses, parasitic infections, tumor immunology, and chronic inflammation. Furthermore, it is a robust preclinical platform for evaluating the efficacy and mechanisms of therapeutic agents targeting the IL-4Rα.
Il4ra-KO
製品ID :
S-KO-16195
系統:
C57BL/6JCya
状況:
説明:
Il4ra is located on chromosome 7 of mice. Nuclease Technology was used to design sgRNA; Il4ra knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Il4ra is located on chromosome 7 of mice. Nuclease Technology was used to design sgRNA; Il4ra knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Il4ra-KO
製品ID :
S-KO-02650
系統:
C57BL/6JCya
状況:
説明:
Il4ra is located on chromosome 7 of mice. Nuclease Technology was used to design sgRNA; Il4ra knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Il4ra is located on chromosome 7 of mice. Nuclease Technology was used to design sgRNA; Il4ra knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
huIL4/huIL4RA
製品ID :
C001834
系統:
C57BL/6NCya
状況:
説明:
Interleukin-4 (IL-4) and its receptor, IL-4R, are pivotal regulators of immune responses and inflammation. The IL4 gene encodes the IL-4 cytokine, a multifunctional protein predominantly secreted by Th2 cells, mast cells, and eosinophils, while the IL4R gene encodes the IL-4 receptor, which is expressed on a variety of immune cells, including B cells, T cells, macrophages, and endothelial cells. IL-4 binds to IL-4R, which exists in two distinct forms: Type I (comprising IL-4Rα and the common γ-chain) and Type II (comprising IL-4Rα and IL-13Rα1) [1]. This interaction activates the JAK-STAT signaling pathway, driving Th2 cell differentiation, B cell class switching to IgE, and anti-inflammatory responses. The IL-4/IL-4R signaling axis is critically implicated in allergic diseases such as asthma, atopic dermatitis, and allergic rhinitis, as well as in parasitic infections and certain cancers [2-5]. Dysregulation of this pathway underlies various pathological conditions, positioning IL-4Rα as a promising therapeutic target. For instance, dupilumab, a monoclonal antibody targeting IL-4Rα, has been approved for the treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyps, underscoring the therapeutic potential of modulating this pathway [6-7].
The huIL4/huIL4RA mouse model is generated by crossing IL4 humanized mice (Catalog Number: C001628) with IL4R humanized mice (Catalog Number: C001629), resulting in a dual-humanized model. This model faithfully recapitulates the human IL-4/IL-4R signaling pathway, making it an invaluable tool for studying allergic diseases (e.g., asthma and atopic dermatitis), Th2 immune responses, parasitic infections, tumor immunology, and chronic inflammation. Furthermore, it serves as a robust preclinical platform for evaluating the efficacy and mechanisms of therapeutic agents targeting the IL-4/IL-4Rα pathway.
Interleukin-4 (IL-4) and its receptor, IL-4R, are pivotal regulators of immune responses and inflammation. The IL4 gene encodes the IL-4 cytokine, a multifunctional protein predominantly secreted by Th2 cells, mast cells, and eosinophils, while the IL4R gene encodes the IL-4 receptor, which is expressed on a variety of immune cells, including B cells, T cells, macrophages, and endothelial cells. IL-4 binds to IL-4R, which exists in two distinct forms: Type I (comprising IL-4Rα and the common γ-chain) and Type II (comprising IL-4Rα and IL-13Rα1) [1]. This interaction activates the JAK-STAT signaling pathway, driving Th2 cell differentiation, B cell class switching to IgE, and anti-inflammatory responses. The IL-4/IL-4R signaling axis is critically implicated in allergic diseases such as asthma, atopic dermatitis, and allergic rhinitis, as well as in parasitic infections and certain cancers [2-5]. Dysregulation of this pathway underlies various pathological conditions, positioning IL-4Rα as a promising therapeutic target. For instance, dupilumab, a monoclonal antibody targeting IL-4Rα, has been approved for the treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyps, underscoring the therapeutic potential of modulating this pathway [6-7].
The huIL4/huIL4RA mouse model is generated by crossing IL4 humanized mice (Catalog Number: C001628) with IL4R humanized mice (Catalog Number: C001629), resulting in a dual-humanized model. This model faithfully recapitulates the human IL-4/IL-4R signaling pathway, making it an invaluable tool for studying allergic diseases (e.g., asthma and atopic dermatitis), Th2 immune responses, parasitic infections, tumor immunology, and chronic inflammation. Furthermore, it serves as a robust preclinical platform for evaluating the efficacy and mechanisms of therapeutic agents targeting the IL-4/IL-4Rα pathway.
B6-huIL4R/huTSLP
製品ID :
C001810
系統:
C57BL/6NCya
状況:
説明:
The B6-huIL4R/huTSLP mouse is a dual-gene humanized model obtained by mating B6-huIL4RA mice (catalog No.: C001629) with B6-huTSLP mice (catalog No.: C001809). This model can be used in the research of allergic diseases (such as asthma and atopic dermatitis), Th2 immune responses, parasitic infections, tumor immunology, chronic inflammation, and autoimmune diseases, as well as in the development of IL-4Rα/TSLP-targeted drugs.
The B6-huIL4R/huTSLP mouse is a dual-gene humanized model obtained by mating B6-huIL4RA mice (catalog No.: C001629) with B6-huTSLP mice (catalog No.: C001809). This model can be used in the research of allergic diseases (such as asthma and atopic dermatitis), Th2 immune responses, parasitic infections, tumor immunology, chronic inflammation, and autoimmune diseases, as well as in the development of IL-4Rα/TSLP-targeted drugs.
huIL4/huIL4R/hOSMR
製品ID :
C002072
系統:
C57BL/6NCya
状況:
説明:
The huIL4/huIL4R/hOSMR mouse is a triple-gene humanized model obtained by crossing the huIL4/huIL4RA mouse (Catalog No.: C001834) with the hOSMR mouse (Catalog No.: C001841). The huIL4/huIL4R/hOSMR mouse is a multi-target humanized model that integrates Th2-type immune-inflammatory regulation with tissue inflammatory response regulation. Co-expressing humanized IL4, IL4R, and OSMR genes, this model can be utilized for the screening, pharmacodynamic evaluation, safety assessment, and mechanism of action studies of multi-target therapeutics targeting IL4, IL4R, and OSMR. It serves as an ideal preclinical research platform for developing innovative therapies for atopic dermatitis (AD) and other Th2-mediated inflammatory diseases.
The huIL4/huIL4R/hOSMR mouse is a triple-gene humanized model obtained by crossing the huIL4/huIL4RA mouse (Catalog No.: C001834) with the hOSMR mouse (Catalog No.: C001841). The huIL4/huIL4R/hOSMR mouse is a multi-target humanized model that integrates Th2-type immune-inflammatory regulation with tissue inflammatory response regulation. Co-expressing humanized IL4, IL4R, and OSMR genes, this model can be utilized for the screening, pharmacodynamic evaluation, safety assessment, and mechanism of action studies of multi-target therapeutics targeting IL4, IL4R, and OSMR. It serves as an ideal preclinical research platform for developing innovative therapies for atopic dermatitis (AD) and other Th2-mediated inflammatory diseases.
huIL4/huIL4R/huTSLP/hTSLPR
製品ID :
C001996
系統:
C57BL/6NCya
状況:
説明:
The huIL4/huIL4R/huTSLP/hTSLPR mice are a quadruple-gene humanized model obtained by mating huIL4/huIL4R mice (catalog number: C001834), huTSLP mice (catalog number: C001809), and hTSLPR mice (catalog number: C001942). This model is a valuable tool for studying allergic diseases (such as asthma and atopic dermatitis), Th2 immune responses, parasitic infections, tumor immunology, and chronic inflammation. In addition, this model also provides a powerful preclinical research platform for evaluating the efficacy and mechanism of therapeutic drugs targeting IL4/IL4R/TSLP/TSLPR.
The huIL4/huIL4R/huTSLP/hTSLPR mice are a quadruple-gene humanized model obtained by mating huIL4/huIL4R mice (catalog number: C001834), huTSLP mice (catalog number: C001809), and hTSLPR mice (catalog number: C001942). This model is a valuable tool for studying allergic diseases (such as asthma and atopic dermatitis), Th2 immune responses, parasitic infections, tumor immunology, and chronic inflammation. In addition, this model also provides a powerful preclinical research platform for evaluating the efficacy and mechanism of therapeutic drugs targeting IL4/IL4R/TSLP/TSLPR.
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